marginal_coefs.Rd
Calculates marginal coefficients and their standard errors from fitted generalized linear mixed models.
marginal_coefs(object, ...) # S3 method for MixMod marginal_coefs(object, std_errors = FALSE, link_fun = NULL, M = 3000, K = 100, seed = 1, cores = max(parallel::detectCores()  1, 1), sandwich = FALSE, ...)
object  an object inheriting from class 

std_errors  logical indicating whether standard errors are to be computed. 
link_fun  a function transforming the mean of the repeated measurements outcome to the
linear predictor scale. Typically, this derived from the 
M  numeric scalar denoting the number of Monte Carlo samples. 
K  numeric scalar denoting the number of samples from the sampling distribution of the maximum likelihood estimates. 
seed  integer denoting the seed for the random number generation. 
cores  integer giving the number of cores to use; applicable only when

sandwich  logical; if 
...  extra arguments; currently none is used. 
It uses the approach of Hedeker et al. (2017) to calculate marginal coefficients from
mixed models with nonlinear link functions. The marginal probabilities are calculated
using Monte Carlo integration over the random effects with M
samples, by sampling
from the estimated prior distribution, i.e., a multivariate normal distribution with mean
0 and covariance matrix \(\hat{D}\), where \(\hat{D}\) denotes the estimated
covariance matrix of the random effects.
To calculate the standard errors, the Monte Carlo integration procedure is repeated
K
times, where each time instead of the maximum likelihood estimates of the fixed
effects and the covariance matrix of the random effects, a realization is used from the
sampling distribution of the maximum likelihood estimates. To speedup this process,
package parallel is used.
A list of class "m_coefs"
with components betas
the marginal coefficients,
and when std_errors = TRUE
, the extra components var_betas
the estimated
covariance matrix of the marginal coefficients, and coef_table
a numeric matrix
with the estimated marginal coefficients, their standard errors and corresponding
pvalues using the normal approximation.
Hedeker, D., du Toit, S. H., Demirtas, H. and Gibbons, R. D. (2018), A note on marginalization of regression parameters from mixed models of binary outcomes. Biometrics 74, 354361. doi:10.1111/biom.12707
Dimitris Rizopoulos d.rizopoulos@erasmusmc.nl
# \donttest{ # simulate some data set.seed(123L) n < 500 K < 15 t.max < 25 betas < c(2.13, 0.25, 0.24, 0.05) D < matrix(0, 2, 2) D[1:2, 1:2] < c(0.48, 0.08, 0.08, 0.18) times < c(replicate(n, c(0, sort(runif(K1, 0, t.max))))) group < sample(rep(0:1, each = n/2)) DF < data.frame(year = times, group = factor(rep(group, each = K))) X < model.matrix(~ group * year, data = DF) Z < model.matrix(~ year, data = DF) b < cbind(rnorm(n, sd = sqrt(D[1, 1])), rnorm(n, sd = sqrt(D[2, 2]))) id < rep(1:n, each = K) eta.y < as.vector(X %*% betas + rowSums(Z * b[id, ])) DF$y < rbinom(n * K, 1, plogis(eta.y)) DF$id < factor(id) ################################################ fm1 < mixed_model(fixed = y ~ year * group, random = ~ 1  id, data = DF, family = binomial()) fixef(fm1)#> (Intercept) year group1 year:group1 #> 2.875293208 0.204144801 0.648693468 0.006044763marginal_coefs(fm1)#> (Intercept) year group1 year:group1 #> 1.3589 0.0966 0.3298 0.0017marginal_coefs(fm1, std_errors = TRUE, cores = 1L)#> Estimate Std.Err zvalue pvalue #> (Intercept) 1.3589 0.1132 12.0052 < 1e04 #> year 0.0966 0.0049 19.5229 < 1e04 #> group1 0.3298 0.1593 2.0701 0.03844 #> year:group1 0.0017 0.0060 0.2795 0.77983 #># }